Simulated treatment comparison (STC) — strategy

Usage

strategy_stc(
  formula = NULL,
  family = gaussian(link = "identity"),
  trt_var = NULL
)

Arguments

formula: Model formula.
family: Model family.
trt_var: Treatment variable name.

Value

stc class object

Details

strategy_stc() was deprecated in outstandR version 1.X.X. We recommend using G-computation (strategy_gcomp_ml()) as a more robust alternative for this type of analysis.

Outcome regression-based method which targets a conditional treatment effect. STC is a modification of the covariate adjustment method. An outcome model is fitted using IPD in the AB trial. For example,

$$ g(\mu_{t(AB)}(X)) = \beta_0 + \beta_1^T X + (\beta_B + \beta_2^T X^{EM}) I(t=B) $$ where $\beta_0$ is an intercept term, $\beta_1$ is a vector of coefficients for prognostic variables, $\beta_B$ is the relative effect of treatment B compared to A at $X=0$, $\beta_2$ is a vector of coefficients for effect modifiers $X^{EM}$ subvector of the full covariate vector $X$), and $\mu_{t(AB)}(X)$ is the expected outcome of an individual assigned treatment $t$ with covariate values $X$ which is transformed onto a chosen linear predictor scale with link function $g(\cdot)$.